100% copper peptides (GHK-cu) Copper Tripeptides - DIY ingredient
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DIY Ingredient - Requires further mixing before use
15 ml GHK-Cu Copper Peptides Fluid
Use rate: 0.5%-2%
For 1% - Add 1 ml GHK Copper Peptides to 99 ml water or base product = produces 100 ml 1% copper peptide product
Add to water phase
Appearance is CLEAR to very, very light blue, but may appear clear when drawn up in pipet or dropper. There is a picture of the way the GHK Copper Peptides look in the jug when we get them - they appear dark blue, like the ocean. Just like the ocean, when you take smaller and smaller quantities to examine for color, the color becomes more clear. If a copper peptide product is a vivid blue, there is way too much GHK copper peptide in it, which can cause skin damage or there could be added blue coloring for marketing purposes. Both should be avoided.
This ingredient has proven effects demonstrated in many of our products including, but not limited to: Rapid Brow, Rapid Hair, Rapid Nail, CP Cuticle Creme, Hi-Rose with Copper Peptides, and Pore Refining Lift. We have been using the same copper peptides from the same chemist for 5-7 years.
Good for at least 1 year from date of purchase.
GHK-cu Copper Peptides - Formulated by a chemist - complete - does not require further synthesizing with protein before use.
The importance of Copper Peptides in your beauty and health care routine has been scientifically proven by many, including Dr. Loren Pickart, PhD. In the same manner Dr. Perricone championed DMAE, Dr. Pickart has championed copper peptides, finding the exact chemical chain needed to be an effective peptide for skin, hair, and nails.
This is a DIY product that can be added at the recommended level to skin, hair and nail serums, creams or preparations.
GHK Copper Peptides should be used at pH levels between 5-7, no lower than 5. For best results, do not use them with acidic preparations lower than pH 5, or with citric acid, ascorbic acid, alpha hydroxy acids, etc. You will be amazed at the results, I promise~!
Copper peptides are used at VERY low concentrations. This is Dr. Sivak's write up on them:
The % concentration we recommend is .0017%. The justification for this can be found below (it is written by Dr. Sivak our resident scientist):
In human serum, copper spontaneously binds to glycyl-histidyl-lysine (GHK), a tripeptide complex that has high affinity for the copper (II) anion. This complex has been shown, both in vitro and in vivo, to accelerate wound healing. One study reported that the addition of GHK-copper complex to human fibroblasts induced a specific, concentration-dependent stimulation of collagen synthesis A later study demonstrated a dose-dependent stimulation of glycosaminoglycan synthesis, specifically heparan sulfate and dermatan sulfate, by adding GHK-copper complex to human skin fibroblasts.
Please note that there are several forms of copper used in the skin care market. The most common are copper gluconate, a copper salt, a mixture of soy protein hydrolizate with copper and the coppper tripeptide. These forms are not equivalent and only the copper tripeptide has been shown to aid in wound healing and to stimulate synthesis of dermis macromolecules.
I suggest that the concentration of copper tripeptide in the finished skin care product is about 2 ppm. I chose this concentration on the basis of the scientific literature available. Why 2 ppm and not a higher concentration? The beneficial effects of copper tripeptide does not show a linear relationship with copper tripeptide concentration. As concentration increases, there is an optimum range and then the benefits decrease. There is also the problem of copper stimulating the activity of proteases, enzymes capable of breaking down collagen and elastin.
I am well aware that skin care manufacturers may be using higher concentrations of copper peptide. There are two possible reasons for this. One is that they are not using copper tripeptide but soy protein hydrolizate, and that the concentration they refer to is that of the protein and not the copper. The second reason is that they may not be aware of the possible drawbacks of copper, although many users have reported problems with commercially available copper products.
Maquart, Francois Xavier; Pickart, Loren; Laurent, Maryvonne; Gillery, Philippe; Monboisse, Jean Claude; Borel, Jacques Paul (1988) Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-copper(2+). FEBS Lett. 238 : 343-6.
Downey, Daniel; Larrabee, Wayne F., Jr.; Voci, Vincent; Pickart, Loren (1985) Acceleration of wound healing using glycyl-histidyl-lysyl copper(II). Surg. Forum: 36 573-5.
May, Peter M.; Whittaker, Jill; Williams, David R. (1983) Copper complexing by growth stimulating tripeptide, glycylhistidyllysine. Inorg. Chim. Acta: 80(1-2), L5-L7.
Wegrowski, Y.; Maquart, F. X.; Borel, J. P (1992) Stimulation of sulfated glycosaminoglycan synthesis by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+. Life Sciences, 51: 1049-56.
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